Live Vaccine Use and Safety in DiGeorge Syndrome
Individuals with DiGeorge syndrome (DGS) have varying degrees of immunodeficiency. All are susceptible to vaccine-preventable infections with serious complications. Although live vaccines are generally contraindicated in this population, limited evidence suggests that they may be effective and safe for select individuals.
Many individuals with DGS received live vaccines despite having a known diagnosis. Adverse events following live immunizations were typically minor and self-limited, suggesting that live vaccines may be considered for patients with DGS who exhibit mild-to-moderate immunosuppression. (Read the full article)
Should Schools Still Play Dodgeball?
Lively debate persists around this playground game, which opponents say is ripe territory for bullies and which supporters argue builds skills like teamwork and resilience.
Live! On Air in Panama
OM Panama team members share on a live radio talk show about the upcoming International Intensive School of Missions.
Live Sustainably Zine - creative books and zines, life zine, art zine, substainable life book.
Live and laugh with dementia : the essential guide to maximizing quality of life / Lee-Fay Low.
Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase
Excessive fructose consumption is closely linked to the pathogenesis of metabolic disease. Carbohydrate response element-binding protein (ChREBP) is a transcription factor essential for fructose tolerance in mice. However, the functional significance of liver ChREBP in fructose metabolism remains unclear. Here, we show that liver ChREBP protects mice against fructose-induced hepatotoxicity by regulating liver glycogen metabolism and ATP homeostasis. Liver-specific ablation of ChREBP did not compromise fructose tolerance, but rather caused severe transaminitis and hepatomegaly with massive glycogen overload in mice fed a high-fructose diet, while no obvious inflammation, cell death, or fibrosis was detected in the liver. In addition, liver ATP contents were significantly decreased by ChREBP deficiency in the fed state, which was rendered more pronounced by fructose feeding. Mechanistically, liver contents of glucose-6-phosphate (G6P), an allosteric activator of glycogen synthase, were markedly increased in the absence of liver ChREBP, while fasting-induced glycogen breakdown was not compromised. Furthermore, hepatic overexpression of LPK, a ChREBP target gene in glycolysis, could effectively rescue glycogen overload and ATP reduction, as well as mitigate fructose-induced hepatotoxicity in ChREBP-deficient mice. Taken together, our findings establish a critical role of liver ChREBP in coping with hepatic fructose stress and protecting from hepatotoxicity by regulating LPK.
Live Q&A on remote working, working from home, and running a business remotely
In this livesteam, David and I answer audience questions about how to work remotely. At Basecamp we’ve been working remotely for nearly 20 years, so we have a lot of experience to share. This nearly 2-hour video goes into great detail on a wide variety of topics. Highly recommended if you’re trying to figure out… keep reading
Live coronavirus updates for Saturday, May 9: Five more Utahns die from COVID-19, bringing state’s death toll to 66
Live coronavirus updates for Friday, May 8: West Jordan canceling the Western Stampede rodeo due to COVID-19 concerns
Live coronavirus updates for Thursday, May 7: Utah minorities especially affected by COVID-19, panelists say
LIVE"GIG"2017～Laugh&Peace・THE FINAL～情報とQ&A
いつも応援ありがとうございます。
いよいよ3月4日5日に10周年を飾る最後のＬＩＶＥ！10th Anniversary LIVE"GIG"2017-THE FINAL-が開催されます。
このライブは加藤和樹作詞・加藤和樹作詞作曲のみで構成された10周年集大成の2日間です。
両日ともチケット完売になっているため急遽、3月5日にはニコニコ動画にて初のＬＩＶＥ生配信をいたします。
まだ加藤和樹のＬＩＶＥを見たことがない方、今回のライブに残念ながら来れなかった方、観てコメントして楽しんでください。
【ニコニコ動画生配信】
3月5日16時より配信開始
http://live.nicovideo.jp/watch/lv290796700
さらに加藤和樹がＭＣをつとめる「ＫＫチャンネル」ではチャンネル会員向けにLIVE本編中「KAZUKIだけカメラ」が発動！
LIVE中、ずっと加藤和樹さんだけを追い続けるカメラを視聴いただくことができます。PCの方は、2窓（2つプラウザを開いて）でお楽しみください。
【ニコ動ＫＫチャンネル・KAZUKIだけカメラ】
http://live.nicovideo.jp/watch/lv291062812
お楽しみください！
◇■◇■ＴＨＥ ＦＩＮＡＬのＱ＆Ａ情報◇■◇■
Q:物販はいつから始まりますか？
A:物販の時間は下記になります。
＜物販開始時間＞
◇3月4日（土）14：30～16：30
◇3月5日（日）13：30～15：30
※公演当日分在庫商品が無くなり次第物販は終了いたします。
※ＦＣに入会されると次回からのライブグッズは会員先行にてライブ当日までに自宅配送され、ライブ当日に並ばず欲しい商品が必ず手に入る特典がございますのでご利用ください。
Q.販売される商品は
A.グッズは下記になります。
＜ＴＨＥ ＦＩＮＡＬグッズ＞
◇Tシャツ（カラー：黒×水色（蓄光つき）/サイズ：S.M.L) 3200円
※蓄光がついたＴシャツ。暗闇で光ります
◇Tシャツ（カラー：ネイビー×ピンク/サイズ：S.M.L) 3200円
◇タオルマフラー 2100円（ジャガード織・今治産）
◇ステンレスボトル 2300円
冷たい飲み物も温かい飲み物も持ち歩けるボトル（容量280ml)
＜Team Kグッズ＞
◇折りたたみ傘 3500円
ついに登場！待望の傘は晴雨兼用・傘袋は濡れたままバックインできる仕様です。
◇シューズから着替えまで入れられるマルチケース 男性用 1300円 女性用 1200円
旅先や学校行事などではシューズケースとして、さらにはたっぷりマチ付なので着替えなどの整理ケースとしても使える便利グッズ。
◇日めくりカレンダー「ＥＶＥＲＹＤＡＹ ＫＡＺＵＫＩ」 2100円
加藤和樹歌詞を日めくりで楽しむカレンダー
＜旧商品＞
◇ブランケット（夏のクーラーのひざ掛けに！） 2000円
◇ライブバック（ライブから普段の買い物まで使えます！カラー：黒/赤） 3500円
＜その他＞
◇周年ライブ限定「ＫＡＺＵ★ＫＵＪＩ」 1口 400円 ※1回５口まで引くことができます。
※この1年の分も追加し、約540種のPHOTO＋チェキなどがランダムに引け、同じ絵柄はなかなか出てこない“ＫＡＺＵ★ＫＵＪＩ”。
中には加藤和樹＆THE DRASTICS直筆サインパネル、
ライブ終演後本人との面会出来ちゃう券などのレア景品も入っています！
◇チャリティーステッカー
「Pray for KUMAMOTO」と書かれたステッカーを募金していただいた方にはお配りしています。
Q:ライブ時間はどのくらいですか？
A:ライブの時間は140分前後になります。
Q:注意事項はありますか？
A:
・光るもの、鳴り物は禁止しております。また、録音録画も禁止です。
・荷物の多い方は、予めコインロッカーなどにお預けください。
・前の人を押し出しする行為をしないようお願いいたします。
Q:物販は開場中、終演後でも購入できますか？
A:基本、購入できるようにしておりますが、数量が無くなり次第終了いたします。
Q:チケットAの引換はどこになりますか？
A:【ＶＯＩＣＥ受付】にて引換をいたします。入場前に必ず受け取ってから入場列に並んでください。
Q:当日券はありますか？
A:当日券の発売はございません。
Q:お花などを送りたいのですが。。。
A:今回はお花は会場の都合上お断りいたしております。
Q:プレゼントを渡したいのですが。。。
A:会場ロビーにプレゼント箱を用意しております。但し、本人に渡すまでに日数がかかりますので食べ物系などはお断りさせていただきます。
Coronavirus outbreak: Live updates
Live Science will keep you up to date on all coronavirus news, including how far it has spread, city and local closings and the science behind the virus and the disease it causes, COVID-19.
Coronavirus outbreak: Live updates
Live Science will keep you up to date on all coronavirus news, including how far it has spread, city and local closings and the science behind the virus and the disease it causes, COVID-19.
Lives sentenced. Experiences of repeated punishment
Little is known about the effects of repeated imprisonment. Very few research studies have examined how those who are punished by the criminal justice system experience and interpret their sentences. Research that does exist, like my PhD, has largely focused on one single sentence. But people who have served many sentences (in other words, who have long punishment careers), are likely not to experience criminal punishments in isolation, but in the context of their wider lives and previous sentences. The aim of the Lives Sentenced project is to address this gap in the knowledge base by examining the life stories of 35 people with long punishment careers
LIVE. De Wever over eventuele tweede piek: “Normale quarantaine is er een van zieken, niet van gezonde mensen” - Het Laatste Nieuws
LIVE. De Wever over eventuele tweede piek: “Normale quarantaine is er een van zieken, niet van gezonde mensen” Het Laatste Nieuws
Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans
BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1.METHODS We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified.RESULTS All BPZE1 vaccinees showed robust B. pertussis–specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1–specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSION The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGISTRATION ClinicalTrials.gov NCT02453048, NCT00870350.FUNDING ILiAD Biotechnologies, Swedish Research Council (Vetenskapsrådet), Swedish Heart-Lung Foundation.
Live cricket match takes fan into the world of real cricket spirit
Every cricket follower fervently needs to watch real-time cricket suit. Nothing can change the excitement, delights and excitement of real-time cricket suit. Live cricket suit is of much worry for a fan during any recurring series or competitions. Every cricket… Continue Reading
Live Video Replay: Fashion Collective Show
| The Bermuda Fashion Collective Show was held last night [Nov 3] at the Bermuda Society of Arts at City Hall, with a number of styles and models on display and part proceeds to be donated to the Chewstick Foundation. The show included Aura Moniz Jones, Carla Faye Hardtman, Deane Williams, Desiree Riley, Edith Rookes, James Lee, Juliette Dyke, Mikaela Eshe, […] |
Live Video Replay: “Art Walk” Fashion Show
| [Updated] The St. George’s Art Walk is underway this afternoon [Oct 25], with the event featuring displays from artists, musical and dance performances, as well as a fashion show — which is currently taking place and you can tune in and watch it live via our Periscope account. The fashion show is set to feature […] |
Live Nation CEO Outlines Reopening Strategy: Experimenting with Shows In The Fall, Be On Sale in Q3/Q4, Full Scale By 2021
It's going to be a little bit until the big shows.
The post Live Nation CEO Outlines Reopening Strategy: Experimenting with Shows In The Fall, Be On Sale in Q3/Q4, Full Scale By 2021 appeared first on Metal Injection.
Live Nation Electronic Asia Inks Deal With Budweiser For Creamfields Festivals
Together, Creamfields And Budweiser Will Focus On Building Entirely New Content For Dedicated Electronic Music Fans Throughout Asia
AEG Presents and Live Nation offer refunds after consumer anger, lawmaker pressure
Live Nation and AEG Presents will offer refunds to ticketholders whose events have been canceled due to coronavirus.
Live Online Priority Support [Update]
With the launch of Google Talk's new Chatback feature earlier this year and due to certain unresolved issues with ChatStat, we decided to switch back to Google Talk for our Live Online Priority Support Service.
Live tour of design exhibition at historic Austrian castle with curator Alice Stori Liechtenstein as part of VDF
#architektura #architekt #dom #design
Live tour of design exhibition at historic Austrian castle with curator Alice Stori Liechtenstein
#architektura #architekt #dom #design
Live Virtual Classrooms: Making the grade in accessibility
Learn about virtual classroom solutions and best practices that instructors can follow to deliver the most accessible online course despite the limitations of virtual classroom tools.
Live Updates: At Least 124 Oregonians Have Died Of COVID-19
More than 3,000 Oregonians have been diagnosed with the coronavirus as of Friday, and more than 16,000 people in Washington. Both states are gradually easing restrictions, but beaches are still closed.
Live video of NASA's Apollo 11 reached the world thanks to one little dish outside Canberra
When Kevin Gallegos carpooled to work one cold Canberra morning the day ahead wouldn't be typical he and the rest of the team at the Honeysuckle Creek Tracking Station would be instrumental in bringing live footage of Neil Armstrong's first steps on the Moon back to Earth.
LIVExchange conference sees participants nominate animal welfare as critical to live export's future
LIVExchange 2019, an annual live exporters conference and themed 'welfare beyond borders', acknowledges of the public relations problems the trade faces.
Live export industry 'eroded' as summer ban extends, WA exporter faces animal cruelty charges
There are concerns, and equally hopes, that an extension to a ban on live sheep exports and cruelty charges against a live exporter are eroding the livestock exporting industry.
Live export independent observers only required where 'most needed' after policy change
Live export ships on most short voyages to South-East Asia will no longer be required to carry independent observers in a Government policy change applauded by the industry.
Live export probe launched after Australian cattle roped and slaughtered in Indonesia
GRAPHIC WARNING: The Department of Agriculture is investigating the alleged inhumane killing of Australian cattle at the Festival of Sacrifice in Indonesia.
Lives of Australia's 'largely unrecognised' unpaid carers the focus of new campaign, 3-legged challenge
Phoebe is your average 13-year-old, except that when she's not at school, she cares for her mum. She is among one in eight Australians who are unpaid carers, but are "largely unrecognised", something a new awareness campaign hopes to change.
Live export industry braces for the cost of fewer cattle on ships
The number of cattle allowed onboard live export ships is about to be reduced. Industry says the new rule makes no sense and will cause financial pain.
Live sheep exports could be banned after this federal election, but WA breeders warn against it
Some WA sheep breeders are worried a ban could damage the industry, but Labor says the science is clear and if they win government they'll end the live export trade.
Livestock Handling Cup celebrates animal welfare and stockmanship in WA's far north
In the dusty station country of northern Western Australia, a unique competition is highlighting the importance of animal welfare to cattle producers and attracting international attention.
Live: NSW Now: Embattled MP Andrew Constance stripped of senior parliamentary role
MORNING BRIEFING: The NSW Transport Minister will no longer serve as Leader of the House, the latest episode in a tumultuous week for Mr Constance in which he announced his bid for the federal seat of Eden-Monaro before withdrawing from the race 24 hours later.
Live: NSW Now: Rates may increase as councils deal with coronavirus fallout
MORNING BRIEFING: The proposed changes allow councils to apply the rate cap more flexibly and comes as local governments suffer financial hardship from the coronavirus pandemic.
Live: Sydney News: Police on hunt for escaped inmate in Illawarra, Liverpool homes evacuated after fire scare
MORNING BRIEFING: NSW police hunt for Sunjay Dayal, who escaped while undertaking maintenance work in Mount Kiera, while three cars set alight in a garage triggers the fire alarms inside a Liverpool unit block.
Lives at risk on the road from poorly trained truck drivers says a Bunbury heavy haulage operator
CEO of a Bunbury freight company, Mark Mazza wants to see a nationally accredited training scheme for truck drivers.